States » SouthPosted at: Jun 20 2025 6:03PM


Two allogeneic stem cell transplants performed successfully in Kerala

Thiruvananthapuram, June 20 (UNI) Two allogeneic stem cell transplants, including a complex and highly challenging haploidentical (half-match) transplant were performed successfully at KIMS-Health Cancer Centre, marking a significant milestone in South Kerala.
In haploidentical or half-match transplants, the recipient shares only a partial genetic match with the donor, who is usually a family member.
Allogeneic stem cell transplant involves replacing diseased stem cells in the bone marrow with healthy ones from a donor.
The half-match transplant was performed on a 37-year-old woman diagnosed with acute myeloid leukemia (AML). Although her sister was the donor, their incompatible blood groups made the procedure particularly complex.
To further compound the challenge, the patient was also battling multi-drug resistant bacterial infections and aspergillosis — a fungal infection that typically affects immunocompromised individuals.
Post-transplant, she contracted cytomegalovirus (CMV), a viral infection, for which she was treated with antivirals. Despite these life-threatening complications, the patient made a full recovery.
A bone marrow assessment conducted 100 days after the transplant confirmed that she was disease-free.
The second successful transplant involved a 63-year-old male patient, also diagnosed with AML, who underwent an allogeneic transplant from a fully matched sibling donor.
Allogeneic transplants in patients over 60 are relatively rare due to increased risks and potential complications. However, this patient has shown remarkable progress and is in remission as of day 100 post-transplant.
“Haploidentical transplants, especially in cases where blood groups are incompatible, demand an advanced skill set and precision. These two successful procedures are a testament to our commitment to providing high-quality, competent care to our patients,” said Dr. Bijay P Nair, Senior Consultant, and Dr. K. S. Lekshmon and Dr. Aswin V Nair, Associate Consultants, Department of Clinical Hematology and Bone Marrow Transplant, KIMSHEALTH.
According to reports, India performs approximately 2,000 stem cell transplants annually. Dr. Sanooja Pinki from the Department of Transfusion Medicine was also part of the treatment team.
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Tags: #Two allogeneic stem cell transplants performed successfully in Kerala
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