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Ovarian cancer affects nearly 7 in every lakh Indian women, warn expert

Kolkata, May 8 (UNI) Ranking as the third most frequent cancer affecting women in India, ovarian maligancy is found in approximately 6.8 cases per 100,000 females in the country, a renowned expert said here on Thursday quoting Indian Council of Medical Research (ICMR) data
On the occasion of World Ovarian Cancer Day, acclaimed gynaecological oncologist Asima Mukhopadhyay stressed the critical need for early detection in treating ovarian cancer- an insidious malignancy that continues to elude timely diagnosis in the vast majority of cases.
"Ovarian cancer ranks as the third most frequent cancer affecting women in India. Data from the Indian Council of Medical Research (ICMR) indicates that the age-adjusted incidence rate of this disease is approximately 6.8 cases per 100,000 women in India", remarked Dr. Asima Mukhopadhyay.
Mukhopadhyay drew attention to the disparity in survival outcomes based on the stage at diagnosis. While early-stage (I-II) diagnoses boast significantly higher cure rates (up to 90% for stage I and 70% 5-year survival for stage II), a mere 20% of cases are currently detected at these treatable stages.
Tragically, long-term survival plummets to 20% or less when the cancer spreads beyond the pelvis (stages III-IV). Computer simulations offer a promising outlook, suggesting that earlier detection of preclinical disease could lead to a substantial 10–30% improvement in survival rates and prove to be a cost-effective approach.
Mukhopadhyay, whose extensive training and PhD focused on ovarian cancer, claims to have made a discovery in identifying homologous recombination deficiency (HRD) in 50% of epithelial ovarian cancers. This finding is crucial in predicting a patient's response to PARP inhibitors, a significant advancement in personalised treatment.
Her commitment extends to establishing a vital cytoreductive surgery programme and a research group in India. Furthermore, she founded the KolGoTrg, the first Indian group within the Gynaecological Cancer Intergroup, facilitating crucial participation in international clinical trials.
An estimated 10% to 15% of malignancies, including ovarian, breast, oral and prostate cancers, are attributed to inherited genetic mutations, positioning familial predisposition as a significant contributing factor in oncogenesis.
In recent years, risk-reducing surgeries such as salpingectomy (removal of the fallopian tubes) after childbearing - a leading example is the Hollywood star Angelina Jolie, who underwent similar preventive procedures - are being suggested by doctors. Additionally , several longitudinal studies indicate that the use of hormonal contraceptive pills is associated with a significant reduction in ovarian cancer incidence.
In light of ovarian cancer's characteristically asymptomatic progression in its incipient stages oncologists advocate for the initiation of systematic surveillance beginning at age 30, recommending two key diagnostic tools: pelvic ultrasound and serum CA-125 testing, both instrumental in early detection.
Meanwhile, global oncologist experts are joining forces to set up a white paper, urging the World Health Organisation (WHO) to revise its current stance and formally recognise ovarian cancer as a critical public health priority.
Doctors are now urging women and families to learn about the often-overlooked early warning signs of ovarian cancer such as persistent bloating, abdominal discomfort or changes in appetite and seek medical advice without delay.
According to the expert, there are certain changes that one can bring into life, including lifestyle choices, eating habits and daily exercise, which lead to a decrease in the chances of premature cell ageing. UNI NST SSP
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